米诺环素辅助治疗对2型糖尿病牙周炎患者炎症和糖代谢指标的影响

Effects of minocycline adjuvant therapy on indexes of inflammatory reaction and glucose metabolism in periodontitis patients with type 2 diabetes mellitus

目的探讨米诺环素辅助治疗对2型糖尿病牙周炎患者炎症和糖代谢指标的影响。方法选取2013年7月至2016年9月治疗的100例伴2型糖尿病的牙周炎患者作为研究对象,随机分为观察组及对照组,每组50例。对照组采用龈下刮治和根面平整的方法治疗,观察组在对照组的基础上在牙周袋内注入米诺环素,对比2组患者的疗效、炎性指标、糖代谢指标、牙龈相关临床指标及不良反应的发生情况。结果观察组患者的总有效率为96. 0%显著高于对照组的82. 0%,差异有统计学意义(P <0. 05);治疗后,观察组超敏C-反应蛋白、肿瘤坏死因子-α、白介素-1β水平显著低于对照组,差异有统计学意义(P <0. 05);治疗后,观察组糖化血红蛋白、空腹血糖水平较对照组低,差异有统计学意义(P <0. 05);治疗后,观察组牙龈指数、菌斑指数、牙周袋深度、牙槽骨吸收和临床附着水平较对照组低,差异有统计学意义(P <0. 05);对照组及观察组患者不良反应发生率分别为6. 0%,10. 0%,2组患者不良反应比较差异无统计学意义(P> 0. 05)。结论应用米诺环素辅助治疗2型糖尿病牙周炎,不仅可以有效改善患者的牙龈情况及炎性反应,还有助于改善患者的血糖水平,且不良反应发生率低,值得推广应用。

Objective To investigate the effects of minocycline adjuvant therapy on indexes of inflammatory reaction and glucose metabolism in periodontitis patients with type 2 diabetes mellitus.Methods One hundred periodontitis patients with type 2 diabetes mellitus who were treated in our hospital from July 2013 to September 2016 were enrolled as research objects,who were randomly divided into observation group(n=50)and control group(n=50).The patients in control group were treated by subgingival scaling and root planing,however,the patients in observation group,on the basis of control group,were treated by injecting minocycline into the periodontal pocket.The clinical efficacy,inflammatory indexes,glucose metabolism indexes,gingival related clinical indexes and adverse reactions were observed and compared between the two groups.Results The total effective rate in observation group was 96.0%,which was significantly higher than that(82.0%)in control group(P<0.05).After treatment,the levels of hypersensitivity C reactive protein,tumor necrosis factor alpha and interleukin 1 beta in observation group were significantly lower than those in control group(P<0.05),and the levels of glycosylated hemoglobin and fasting blood glucose in observation group were significantly lower than those in control group(P<0.05),moreover,the levels of gingival index,plaque index,depth of periodontal pocket,alveolar bone absorption and clinical attachment in observation group were significantly lower than those in control group(P<0.05).In addition incidence rates of adverse reactions in control group and observation group were 6%and 10%,respectively,there were no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion The application of minocycline adjuvant therapy in treatments of periodontitis patients with type 2 diabetes can not only effectively improve the gingival condition and inflammatory reaction,but also help to improve blood sugar levels,with lower incidence rate of adverse reactions,thus,which is worthy of popularization and application in clinical practice.