肿瘤血管生成拟态形成的机制

Mechanisms of vasculogenic mimicry formation in tumor

血管生成拟态(vasculogenic mimicry,VM)主要是由肿瘤细胞形成的无内皮细胞的管样结构,主要为肿瘤在营养缺乏或侵袭过程中提供血液,与肿瘤的侵袭程度和患者预后相关。其形成的原因涉及多种复杂机制,包括肿瘤微环境诱导的调控蛋白、体内激素、RNA、肿瘤相关免疫细胞和肿瘤细胞的自分泌途径等。本文就近年关于肿瘤中各种分子机制促进VM形成做一简要综述。

The vasculogenic mimicry(VM)is a tube-like structure without endothelial cells mainly formed by tumor cells,which mainly provides blood for tumor during nutritional deficiency or invasion process.It is related to the degree of tumor invasion and patient prognosis.Its formation involves a variety of complex mechanisms,including regulatory proteins induced by the tumor microenvironment,hormones,RNA,tumor-associated immune cells,and autocrine pathways of tumor cells,and so on.This article provides a brief review of the various molecular mechanisms that promote VM formation in tumors in recent years.