原发性稳定型微血管心绞痛患者脂蛋白相关磷脂酶A2与血管舒张功能的关系研究

The relationship of lipoprotein associated phospholipase A_2 and vascular dilation function in patients with primary stable coronary artery microvascular angina

目的观察原发性稳定型微血管心绞痛(PSCAMA)患者血浆脂蛋白相关磷脂酶A2(LpPLA2)和内皮依赖性血管舒张功能以及非内皮依赖性血管舒张功能的关系。方法随机选取2017年1月～2017年6月于郑州大学第一附属医院收治的38例PSCAMA患者为实验组,38例正常的健康人为对照组,应用彩色多普勒超声显像仪测定两组患者的血流介导的血管扩张功能(FMD)和硝酸甘油依赖的血管扩张功能(NMD)。采用ELISA法检测血浆Lp-PLA2水平。结果与对照组相比,PSCAMA组患者FMD显著受损;PSCAMA组患者Lp-PLA2水平明显增加且与FMD呈负相关。而对照组与PSCAMA组相比NMD无统计学差异。结论 PSCAMA患者肱动脉FMD显著降低;血浆Lp-PLA2水平明显增加且与肱动脉FMD呈负相关。

Abstract]Objective To identify the relationship of lipoprotein associated phospholipase A2(Lp-PLA2)and vascular dilation function in patients with primary stable coronary artery microvascular angina(PSCAMA).Methods We studies 38 patients with PSCAMA and 38 normal control patients.Endothelial-dependent nitric oxide-mediated vasodilatory capacity(flow-mediated dilation,FMD)and endothelial-independent nitroglycerin-mediated dilation(NMD)capacity was measured.Lp-PLA2 were measured in plasma using ELISA methodology.Results FMD was markedly impaired in patients with PSCAMA(9.1±1.1%)compared to control group(15.9±1.9%,P<0.05).Plasma Lp-PLA2 was markedly elevated in PSCAMA group(17.2±3.1μg/L vs.9.6±1.8μg/L,P<0.05)and had an inverse relationship with FMD(r=-0.53,P<0.05).There was no difference about NMD between the two groups.Conclusion The levels of plasma Lp-PLA2 was elevated in PSCAMA group and inversely correlated with FMD.