大株红景天与单硝酸异山梨酯治疗稳定型心绞痛的疗效比较

Comparison in curative effects between Rhodiola Sachalinensis Injection and isosorbide mononitrate in treatment of stable angina pectoris

目的探究大株红景天和单硝酸异山梨酯分别治疗稳定型心绞痛的效果观察。方法选取2016年1月～2017年1月于北京协和医院心内科治疗的稳定型心绞痛患者110例,根据随机数字表法分为Ⅰ组(55例)和Ⅱ组(55例)。Ⅰ组中男性31例、女性24例、年龄(51.33±5.42)岁;Ⅱ组中男性32例、女性23例、年龄(52.54±6.63)岁。在常规治疗基础上Ⅰ组联合大株红景天治疗,Ⅱ组联合单硝酸异山梨酯治疗,14 d为一疗程。观察治疗前后两组患者的疗效、血液流变学指标等。结果治疗后,Ⅰ组疗效和心电图改变均显著高于Ⅱ组(P<0.05);Ⅰ组全血比黏度、纤维蛋白原、血小板黏附率、血浆比黏度显著低于Ⅱ组(P<0.05);两组不良反应,无统计学差异(P>0.05)。结论大株红景天治疗稳定型心绞痛可有效改善患者机体供血状态,改善心脏微循环,具有较高的临床应用价值。

Objective To investigate the curative effects of Rhodiola Sachalinensis Injection and isosorbide mononitrate on stable angina pectoris(SAP).Methods SAP patients(n=110)were chosen from Department of Cardiology of Peking Union Medical College Hospital from Jan.2016 to Jan.2017,and then randomly divided into group I(n=55,male 31,female 24 and age=51.33±5.42)and group II(n=55,male 32,female 23 and age=52.54±6.63).Besides of routine treatment,group I was given Rhodiola Sachalinensis Injection and group II was given isosorbide mononitrate for 14 d as one therapeutic course.The curative effect and hemorrheological indexes were observed in 2 groups before and after treatment.Results The curative effect and ECG changes were all significantly higher in group I than those in group II(P<0.05)after treatment.The whole blood viscosity,fibrinogen(FIB),platelet adhesion rate and plasma specific viscosity were significantly lower in group I than those in group II(P<0.05).The incidence of adverse reactions had no statistical difference between 2 groups(P>0.05).Conclusion Rhodiola Sachalinensis Injection can effectively improve blood supply and cardiac microcirculation in SAP patients,and it has higher clinical value.