RDW、NLR与老年人心房颤动发生的关联性研究

The relationship among red cell distribution width, neutrophil to lymphocyte ratio and the occurrence of atrial fibrillation in the elderly

目的探讨红细胞分布宽度(RDW)及中性粒细胞淋巴细胞比值(NLR)与老年人房颤发生的相关性。方法选择2016年1月～2017年6月于华北理工大学附属医院老年病科和心内科住院的168例老年人房颤患者作为房颤组,进一步将其分为阵发性房颤亚组97例,持续性/长程持续性/永久性房颤亚组71例。另选取与房颤组对象同一时间住院的且同房颤组对象性别相同、年龄相近的168例老年非房颤患者作为对照组。收集房颤组与对照组患者的RDW、NLR值,并分析其与老年人房颤发生的相关性。结果与对照组相比,房颤组RDW、NLR明显升高,差异具有统计学意义(P均<0.05),两亚组比较显示,持续性/长程持续性/永久性房颤亚组RDW、NLR水平均高于阵发性房颤亚组,差异具有统计学意义(P均<0.05)。多因素logistic回归分析显示RDW、NLR是老年人发生房颤的独立危险因素(OR=2.036、2.855,95%CI:1.060～3.908、1.040～7.833,P=0.033、0.042)。结论 RDW、NLR水平升高与老年人房颤的发生和维持有关,RDW、NLR是老年人房颤发生的独立危险因素。

Objective To investigate the relationship between the red blood cell distribution width(RDW),neutrophil to lymphocyte ratio(NLR)and the occurrence of atrial fibrillation in the elderly.Methods From 2016 January to 2017 June,168 elderly patients with atrial fibrillation were enrolled as atrial fibrillation group(AF group).The AF group was furtherly divided into paroxysmal atrial fibrillation subgroup(97 cases)and persistent/long-standing persistent/permanent atrial fibrillation subgroup(71 cases).168 patients with non-atrial fibrillation who were older than 60 years old were selected as the control group.The admission time,age and gender of control group were the same as the AF group.RDW and NLR from the AF group and the control group were collected.The correlation between these data and the occurrence of atrial fibrillation in the elderly was analyzed.Results There were statistical differences of RDW and NLR between control group and AF group(all P<0.05).Compared with paroxysmal atrial fibrillation subgroup,RDW and NLR in persistent/long-standing persistent/permanent atrial fibrillation subgroup increased statistically(all P<0.05).Multivariate logistic regression analysis showed that RDW and NLR are independent risk factors for the occurrence of atrial fibrillation in the elderly(OR=2.036,2.855;95%CI:1.060~3.908,1.040~7.833;P=0.033,0.042).Conclusion Elevated levels of RDW and NLR are related to the occurrence and maintenance of elderly patients with atrial fibrillation.RDW and NLR are independent risk factors for the occurrence of atrial fibrillation in the elderly.