老年高血压患者同型半胱氨酸水平调查分析

Investigation and analysis of homocysteine level in elderly hypertensive patients

目的:探讨老年高血压患者与同型半胱氨酸的关系;方法:选择内科住院患者254例,分为高血压组和无高血压组(对照组),并对≥60岁及<60岁患者的Hcy情况进行分析。结果:高血压组体重指数高于对照组,吸烟、饮酒、高脂血症、糖尿病,高血压发病率高于对照组(P<0.05)。高血压组高Hcy例数明显多于对照组(P<0.01)。高血压组男女Hcy水平均显著高于对照组;而自身对照,两组男性Hcy水平均高于女性,高血压组与对照组Hcy水平均随着年龄增长而增长,≥60岁Hcy水平明显高于<60岁人群(P<0.05)。结论:血浆Hcy增高是高血压的独立危险因素,Hcy水平在性别上的差异可能与膳食结构、性激素、酶活性等因素有关。有效控制老年H型高血压对预防老年心脑血管事件的发生,改善其预后具有重要的意义。

Objective:To investigate the relationship between homocysteine and elderly hypertensive patients.Methods:254 inpatients in internal medicine were selected,they were divided into the hypertension group and the non hypertension group(the control group),Hcy status of patients over 60 years of age and below were analyzed.Results:In the hypertension group,body mass index was higher than that in the control group,smoking,drinking,hyperlipidemia,diabetes and hypertension were higher than those in the control group(P<0.05).In the hypertension group,the number of high Hcy was significantly higher than that in the control group(P<0.01).In hypertension group,the Hcy level of male and female was significantly higher than that of the control group,and in the hypertension group and the control group,the level of Hcy in male was higher than that of women,in the hypertension group and the control group,the level of Hcy was increased with age,the level of Hcy above 60 years old was significantly higher than that of people under 60 years old(P<0.05).Conclusion:Elevated plasma Hcy was an independent risk factor for hypertension,gender differences in HCY levels may be related to dietary structure,sex hormones,enzyme activity and other factors.Effective control of elderly type H hypertension was of great significance to prevent the occurrence of cardiovascular and cerebrovascular events in the elderly and improve its prognosis.