活化型NOCTCH1弥漫着色与NOCTCH1基因突变状态相关且与腺样囊性癌预后差密切相关

Diffuse staining for activated NOTCH1 correlates with NOTCH1 mutation status and is associated with worse outcome in adenoid cystic carcinoma

腺样囊性癌是一种罕见的唾液腺来源的癌,多发生于头颈部、上呼吸道及乳腺。肿瘤虽生长缓慢,但多侵犯神经并远处转移致预后差。由于腺样囊性癌中常存在NOTCH1基因突变,为进一步证实免疫组化NOTCH1染色能检测腺样囊性癌伴NOTCH1突变,作者将173例患者的197次活检确诊为腺样囊性癌病例行活化型NOTCH1(NICD1)免疫组化染色并分析。