The role of Si-Jun-Zi decoction in the management of gastric precancerous lesions and its mechanism

Gastric cancer remains one of the most common and aggressive malignant tumors worldwide.The occurence of gastric cancer experiences a cascade of multistep gastric carcinogenesis,starting from inflammation,metaplasia,and ultimately to dysplasia and carcinoma.Patients with gastric precancerous lesions,mainly including intestinal metaplasia and dysplasia,are more prone to suffer from gastric adenocarcinoma[1].Therefore,early prevention and treatment regarding gastric precancerous lesions is an important way to reduce the risk of occurence of gastric cancer.