酒精性肝病79例临床特征分析

Clinical features of alcoholic liver diseases:An analysis of 79 cases

目的分析酒精性肝病患者的临床特征。方法按照酒精性肝病诊断标准,将2009年1月～2015年1月期间我院消化科收治的酒精性肝病患者79例纳入回顾性病例对照研究,其中肝硬化患者56例,非肝硬化患者23例。住院期间戒酒者44例,结果出现酒精戒断综合征(AWS)者20例,无AWS者24例。结果酒精性肝硬化组年龄为(54.3±7.1)岁,总饮酒量为(5607.3±3667.0)g/年,均显著大于或多于非肝硬化组[(45.1±10.1)岁,(3884.5±2509.4)g/年,P<0.05];AWS组每日饮酒量为(222.1±121.5)g,总饮酒量为(5520.4±4400.1)g/年,均显著大于非AWS组[(139.5±92.2)g)和(4274.3±3136.8)g/年,P<0.05]。结论饮酒时间长和饮酒量大是导致酒精性肝硬化的主要原因,而这些患者不适当的戒酒可能会导致酒精戒断综合征,应注意预防和给予及时的处理。

Objective To investigate the clinical features of alcoholic liver disease and alcohol withdrawal syndrome(AWS).Methods 79 patients were enrolled according to the guideline for management of alcoholic liver disease at our Department of Gastroenterology between 2009 and 2015,including 56 patients with liver cirrhosis,and 20 out of 44 patients showed alcohol withdrawal syndrome after abstinence.Results There were statistical differences as respect to age(54.3±7.1 years vs.45.1±10.1 years)and total drinking consumption(5607.3±3667.0 g/year vs.3884.5±2509.4 g/year)in patients with liver cirrhosis and those without(P<0.05);there were statistical difference as respect to daily drinking consumption(222.1±121.5 g vs.139.5±92.2 g)and total drinking consumption(5520.4±4400.1 g/year vs.4274.3±3136.8 g/year)in patients with AWS and non-AWS(P<0.05).Conclusions Long and huge alcohol consumption might lead to alcoholic liver cirrhosis,and inappropriate abstinence might induce alcohol withdrawal syndrome,which must be take into consideration in clinical practice.