全胰腺切除联合自体胰岛移植治疗慢性胰腺炎1例报道并文献复习

Total pancreatectomy-islet autotransplantation in treatment of chronic pancreatitis: report of one case and literature review

目的探讨全胰腺切除联合自体胰岛移植(TP-IAT)治疗慢性胰腺炎的临床疗效。方法佛山市第一人民医院对1例合并多发假性囊肿、胰腺结石的难治性慢性胰腺炎患者行TP-IAT治疗,并对其随访3个月的临床资料进行总结与分析。结果患者TP-IAT术后恢复顺利,无发生出血、严重低血糖等并发症,腹痛完全缓解,未服用镇痛药物。随访期间患者使用外源性胰岛素,空腹血糖控制理想,胰岛细胞功能部分恢复。结论 TP-IAT既能缓解慢性胰腺炎的临床症状,也能预防术后糖尿病的发生,是治疗难治性慢性胰腺炎的有效手段。

Objective To evaluate the clinical efficacy of total pancreatectomy-islet autotransplantation(TP-IAT)in the treatment of chronic pancreatitis.Methods One patient diagnosed with refractory chronic pancreatitis complicated with multiple pseudocysts and pancreatic stones underwent TP-IAT in the First People's Hospital of Foshan.Clinical data were collected and analyzed during postoperative 3 months follow-up.Results The patient was well recovered after TPIAT without complications,such as bleeding and severe hypoglycemia.Abdominal pain was completely relieved without taking analgesic drugs.During postoperative follow-up,the patient was treated with exogenous insulin,the fasting blood glucose was properly controlled and the function of islet cells was partially restored.Conclusions TP-IAT can not only relieve the clinical symptoms of chronic pancreatitis,but also prevent postoperative diabetes mellitus,which is an efficacious treatment of refractory chronic pancreatitis.