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心脏压力超负荷状态下内源性心脏保护作用机制研究进展 被引量:2

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摘要 心脏压力超负荷状态普遍存在于心血管疾病中,其可以引起心肌细胞肥大、心肌纤维化及细胞能量代谢障碍,导致心肌收缩舒张功能障碍,最终引发心功能衰竭。在心脏压力超负荷状态下,机体主要通过调控特定的生长因子、基因、受体、蛋白及离子通道的表达或者依靠自身保护因子的机制来对抗心肌重塑、改善心肌能量代谢、对抗心肌离子通道异常、改善心肌供血环境及减少心肌细胞自噬等,实现内源性心脏保护作用。
作者 梁宇明 何燕
出处 《山东医药》 CAS 2018年第40期88-90,共3页 Shandong Medical Journal
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