脓毒症引起心肌病的研究进展

Advances in research on sepsis-induced cardiomyopathy

脓毒症是机体对感染反应的失控引发的危及生命的全身性疾病,特点是发病率高、病死率高和花费高。尽管大量的研究发现各种有益的治疗方法,但临床获益不明显,脓毒症的总体病死率并未降低。而脓毒症引起脏器损伤的患者,尤其心脏功能障碍,其病死率更高。因此,改善脓毒症后的心功能障碍和心肌损伤能改善患者的预后。本文对近期脓毒症引起心肌损伤的机制和相关治疗方法的研究进展进行综述。

Sepsis,the uncontrolled organism??s response to an infection,triggers life-threatening systemic disease characterized by high morbidity,high motality and high costs.Although a large number of studies have found various beneficial treatments,the clinical benefit is not obvious,and the overall mortality rate of sepsis has not decreased.The sepsis caused organ damage,especially heart dysfunction,has a higher mortality.Therefore,to improve cardiac dysfunction and myocardial injury after sepsis can improve the prognosis of patients.This article reviews on the recent progress in the mechanism of sepsis-induced myocardial damage and the improvement of related treatment methods.