应用二维超声联合XI-VOCAL容积测量技术评估胎儿胆囊与孕周的关系

Evaluation of fetal gallbladder and gestational age by two-dimensional ultrasound combined with XI-VOCAL volume measurement

目的建立胎儿胆囊二维测值与相应孕周的正常值范围;应用XI-VOCAL容积测量技术,获得胎儿胆囊容积生长曲线方程,探讨胎儿胆囊容积与孕周的关系。方法选取2014年12月—2017年8月于本院行产前筛查的556例13～40周的单胎胎儿,孕妇无妊娠并发症且长期生活在成都地区,测量胎儿胆囊二维径线,采集孕22～32周260例胎儿胆囊容积,利用XI-VOCAL容积测量技术估算胎儿胆囊容积。结果正常胎儿胆囊二维、容积测值与孕周呈正相关,二维测值快速便捷,容积测值更为精确。结论胎儿胆囊大小异常多与染色体疾病相关,建立胎儿胆囊大小参考值对胎儿胆道系统发育情况、及早发现不良妊娠结局均有重要意义,二维超声联合容积成像可为观察胎儿胆系异常提供有价值的信息。

Objective To establish the normal range of two-dimensional(2D)ultrasound fetal gallbladder measurement and corresponding gestational weeks and to obtain the growth curve equation of fetal gallbladder volume by XI-VOCAL volumetric measurement technique,and to explore the relationship between fetal gallbladder volume and gestational weeks.Methods 556 single fetuses with 13 to 40 weeks of gestation were screened in our hospital from December 2014 to August 2017.Inclusion criteria was women who lived in Chengdu for a long time without pregnancy complications.The 2D ultrasound diameter of fetal gallbladder was measured and fetal gallbladder volumes of 260 infants with 22 to 32 weeks of gestation were collected.The volume of fetal gallbladder was estimated by XI-VOCAL.Results The 2D ultrasound measurement and XI-VOCAL volumetric measurement of fetal gallbladder among healthy infants was positively correlated with gestational age.The 2D ultrasound gallbladder volume measurement was fast and convenient,and the XI-VOCAL volume measurement was more accurate.Conclusion The abnormal size of fetal gallbladder is mostly related to chromosomal diseases.It is important to establish the reference value of fetal gallbladder size for the development of fetal biliary tract system and the early detection of adverse pregnancy outcomes.2D ultrasound combined with volume imaging can provide valuable information for the diagnosis of fetal biliary abnormalities.