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猕猴新型立体宫内节育器避孕效果观察

Observation on the contraceptive effect of a new stereoscopic intrauterine device for rhesus macaques
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摘要 目的研制并观察猕猴立体网状镍钛记忆合金宫内节育器(SIUD)避孕效果及成年雌性猕猴子宫内膜改变情况。方法猕猴SIUD支架所用材料为镍钛记忆合金丝,编织成网格状支架,外包硅橡胶。在福建省计划生育科学技术研究所福建省福州市灵长类动物实验基地,选取成年已生育的雌性健康猕猴18只,进行子宫外部测量,分为手术放置SIUD组(实验组)和对照组,每组各9只。结果猕猴SIUD支架为心形或倒梨形,上端横径长度0. 4~0. 8 cm,下端横径长度0. 3~0. 6 cm,高度0. 6~1. 2 cm,支架厚度0. 2~0. 3 cm。镍钛记忆合金支架在25℃以下缩形为直线状,在体温36~37℃恢复其结构;硅橡胶涂膜防止镍钛合金丝与组织粘连。猕猴子宫外部测量:长度、宽度及厚度分别为(27. 1±2. 1) mm、(20. 8±2. 4) mm及(17. 5±2. 1) mm;卵巢为(9. 5±0. 9) mm、(7. 3±0. 7) mm及(7. 1±0. 7) mm,输卵管长度为(4. 2±0. 6) cm。实验组9只猕猴顺利放置新型SIUD,3个月1只SIUD脱落后妊娠,脱落率及妊娠率均为11. 1%,其余8只未脱落,均无妊娠;对照组9只都妊娠(P <0. 05)。结论猕猴子宫形状与人类相似度高,是研制新型SIUD的较好动物模型,猕猴SIUD具有较好的避孕效果。 Objective To develop and observe the contraceptive effect of a new stereoscopic intrauterine device(SIUD)and the change of endometrial in adult female Rhesus macaque.Methods The scaffold of SIUD used in rhesus macaque was made of nickel-titanium memory alloy wires and woven into a grid-shaped,covered the layer of silicone rubber.18 Adult female Rhesus macaques were selected for external measurement of uterus,ovary and oviducts in the Fujian provincial family planning science and Technology Institute,primate experimental base in Fuzhou,Fujian.The SIUD(experimental)group(n=9)and control group(n=9)were divided.Results The stent of Rhesus macaque SIUD was heart-shaped or inverted pear-shaped,the length of the upper,lower diameter and height was 0.6~0.8 cm,0.3~0.4 cm and 0.6~1.2 cm respectively with the thickness 0.2~0.3 cm.The Ni-Ti memory alloy stent was reduced to a straight line below 25℃,and its structure was restored at the body temperature of 36~37℃.The silicone rubber coating prevented the adhesion between NiTi alloy wire and tissue.The external measurement including the length,width and thickness was(27.1±2.1)mm,(20.8±2.4)mm and(17.5±2.1)mm respectively for uterus,and(9.5±0.9)mm,(7.3±0.7)mm and(7.1±7.1)mm respectively for ovary,and the length of fallopian tube was(4.2±0.6)cm.Nine rhesus macaque in experimental group were successfully inserted in a new SIUD,and 1 of them was fell off in 3 months,all other eight SIUD did not fell off and the macaques were not pregnant,with the rate of shedding and pregnant was 11.1%(1/9).All nine rhesus macaques in control group were pregnant(P<0.05).Conclusion The shape of Rhesus macaque was similar to that of human beings,and it’s a good animal model for the development of a new SIUD.Our study showed that SIUD has a good contraceptive effect in Rhesus macaque.
作者 于玲 张美华 宋霞 李志雄 翟丽屏 于建春 邱毅 YU Ling;ZHANG Meihua;LI Zhixiong;YU Jianchun;QIU Yi(Key Laboratory of Birth Regulation and Control Technology of National Health and Family Planning Commission of China,Key Laboratory for Improving Birth Outcome Technique,Maternal and Child Health Care Hospital of Shandong Province,Shandong Provincial Family Planning Institute of Science and Technology,Shandong 250014,China)
出处 《中国生育健康杂志》 2018年第6期536-540,602,共6页 Chinese Journal of Reproductive Health
基金 国家重点研发计划-"基于新材料的安全高效新型宫内节育器研发"(2016YFC1000903)
关键词 立体网状宫内节育器 猕猴 子宫 镍钛记忆合金丝 避孕 stereoscopic intrauterine device(SIUD) rhesus macaque uterus nickel-titanium memory alloy wire contraception
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