糖尿病肾病与甲状腺激素水平的相关性分析

A correlation analysis of diabetic nephropathy and thyroid hormone levels

目的:分析糖尿病肾病与甲状腺激素水平的相关性。方法:选取确诊为糖尿病的患者130例作为实验组,并且选取我院健康的40例体检者作为对照组,收治时间为2015年5月-2017年5月,实验组中剔除4例临床甲状腺功能减退以及3例甲状腺功能亢进,剩余123例糖尿病患者按照GFR(肾小球滤过率)以及UAER(尿蛋白排泄率)(两周内检查三次取平均值)分组,对比不同组别患者的TSH(促甲状腺激素)、FT4(游离T4)以及FT3(游离T3)水平的差异。结果:随着糖尿病肾病病情的加重,FT3有下降的趋势,按照UAER所分组的各组间的比较差异不显著;按照GFR所分组的各组间的GFR31～60mL/min以及GFR≤30m L/min组低于GFR≥90mL/min组;TSH、FT4所有分组的组间比较差异均不具有统计学意义(P> 0.05)。结论:糖尿病肾病患者的甲状腺激素水平存在不同程度的降低,并且甲状腺激素水平与糖尿病肾病呈负相关,甲状腺激素水平的检测对于临床上鉴别糖尿病肾病具有重要的指导意义。

Objective:To analyze the correlation between diabetic nephropathy and thyroid hormone levels.Methods:130 patients with diabetes mellitus were selected as the experimental group,and 40 healthy people in our hospital were selected as the control group.The treatment time was from May 2015 to May 2017.4 cases of clinical hypothyroidism and 3 cases of hyperthyreosis were kicked out in the experimental group.123 cases with diabetes were grouped according to GFR and UAER(average three times within two weeks).The difference in TSH,FT4,and FT3 levels between groups were compared.Results:With the aggravation of diabetic nephropathy,FT3 showed a downward trend.The difference between the groups grouped according to UAER was not significant.The thyroid hormone levels in the GFR31~60mL/min group and GFR≤30mL/min group grouped according to GFR was lower than the GFR≥90mL/min group.The difference between the groups of TSH and FT4 was not statistically significant(P>0.05).Conclusion:The levels of thyroid hormones in patients with diabetic nephropathy are decreased to some extent,and the level of thyroid hormone is negatively correlated with diabetic nephropathy.The detection of thyroid hormone levels has important guiding significance for the clinical identification of diabetic nephropathy.