甘精胰岛素联合瑞格列奈对老年2型糖尿病的治疗作用研究

Study on the therapeutic effects of insulin glargine combined with repaglinide in the treatment of elderly patients with type 2 diabetes mellitus

目的:探讨甘精胰岛素联合瑞格列奈对老年2型糖尿病的治疗作用。方法:收治老年2型糖尿病患者90例,分两组,每组各45例。对照组给予甘精胰岛素治疗,观察组给予甘精胰岛素联合瑞格列奈治疗。比较相关指标。结果:观察组转归效果优于对照组(P<0.05);观察组血糖控制达标时间、胰岛素消耗量优于对照组(P<0.05);治疗后观察组早餐后2 h血糖、空腹血糖、体重指数和糖化血红蛋白优于对照组(P<0.05);观察组低血糖事件出现率低于对照组(P<0.05)。结论:甘精胰岛素联合瑞格列奈治疗老年2型糖尿病的疗效确切,可有效改善症状,减少胰岛素用量,促进血糖达标,控制体重,减少不良反应。

Objective:To investigate the therapeutic effect of insulin glargine combined with repaglinide in the treatment of elderly patients with type 2 diabetes mellitus.Methods:90 elderly patients with type 2 diabetes were selected,they were divided into the two groups.The control group was treated with insulin glargine,while the observation group was treated with insulin glargine combined with repaglinide.We compared the relevant indicators.Results:The outcome of the observation group was higher than that of the control group(P<0.05).The blood glucose control time and insulin consumption in the observation group were better than those in the control group(P<0.05).After treatment,the plasma glucose 2 h after the breakfast fasting blood glucose,body mass index and glycosylated hemoglobin in the observation group were better than those in the control group(P<0.05).The incidence of hypoglycemia in the observation group was lower than that in the control group(P<0.05).Conclusion:Insulin glargine combined with repaglinide in the treatment of elderly type 2 diabetes mellitus is effective,can effectively improve symptoms,reduce insulin dosage,promote blood glucose standards,control weight,reduce adverse reactions.