拜阿司匹林联合氯吡格雷治疗急性期脑梗死的临床观察

Clinical observation of aspirin combined with clopidogrel in the treatment of acute cerebral infarction

目的:探究拜阿司匹林联合氯吡格雷治疗急性期脑梗死的临床治疗效果。方法:收治急性期脑梗死患者90例,随机分为两组,每组各45例。对照组患者在常规治疗的基础上予以服用拜阿司匹林,治疗组在此基础上增加服用氯吡格雷。比较两组患者治疗14 d后的临床治疗效果。结果:治疗14 d后,治疗组患者生活自理能力明显优于对照组,治疗组患者神经功能缺损评分显著低于对照组(P<0.05)。治疗组患者的血小板聚集率、纤维蛋白原、血浆黏度等指标明显低于对照组(P<0.05)。两组患者治疗期间均未出现明显不良反应。结论:拜阿司匹林联合氯吡格雷治疗急性期脑梗死有很好的临床效果,能够明显改善患者的生活质量。

Objective:To explore the clinical effect of aspirin combined with clopidogrel in the treatment of acute cerebral infarction.Methods:90 patients with acute cerebral infarction were selected,they were randomly divided into the two groups.Patients in the control group were given aspirin on the basis of conventional treatment,the treatment group added clopidogrel on this basis.The clinical effects of the two groups of patients after 14 days treatment were compared.Results:After 14 days of treatment,the life self-care ability of the treatment group was significantly higher than that of the control group,the neurological deficit score in the treatment group was significantly lower than that in the control group(P<0.05).The platelet aggregation rate,fibrinogen and plasma viscosity of the treatment group were significantly lower than those of the control group(P<0.05).No obvious adverse reactions were observed in the two groups during treatment.Conclusion:The combination of aspirin and clopidogrel has a good clinical effect in the treatment of acute cerebral infarction,and can significantly improve the quality of life of patients.