骨碎补总黄酮的实验及临床研究概况

Basic and clinical research of total flavonoids from drynaria fortunei

骨碎补总黄酮作为从中药骨碎补中提取的有效成分,被广泛应用于实验及临床研究。特别是在骨质疏松方面的研究尤为突出,从分子通路,如BMP-Smads信号通路、Wnt/β-catenin通路、MAPK信号通路、CTSK信号通路及OPG/RANKL/RANK信号通路等,到体内雌激素水平、体外细胞、骨组织及临床研究等,从不同的层面论证了骨碎补总黄酮抗骨质疏松的作用。骨碎补总黄酮还可以治疗骨折、骨缺损、膝骨关节炎、类风湿关节炎、股骨头坏死、骨牵张技术等。骨碎补总黄酮在治疗各种不同骨科疾病时,可通过相同的分子蛋白通路发挥作用,从微观角度体现了中医异病同治的治疗特点。虽然骨碎补总黄酮在基础研究及临床治疗方面应用广泛,但是其作用机理仍有待探究,不同分子通路之间的相互作用需要进一步明确。另外,骨碎补总黄酮仍然属于混合成分,其中柚皮苷的作用较为突出,但是并不能完全代替骨碎补总黄酮的作用,需要进一步分离提取,更精准地找到治疗不同骨科疾病不同靶点的有效成分。

Total flavonoids from drynaria fortunei,an effective component extracted from drynaria fortunei,have been widely used in basic and clinical research,especially in osteoporosis research.Research at different levels has been conducted to prove the effect of drynaria fortunei flavonoids on osteoporosis,from molecular pathways,such as BMP-smads signal pathway,Wnt/β-catenin pathway,MAPK signal pathway,CTSK signal pathway and OPG/rankl/rank signal pathway,to in vitro cells,bone tissue and clinical research.In addition,the total flavonoids of Rhizoma drynariae can also be used for treating fracture,bone defect,knee osteoarthritis,rheumatoid arthritis,femoral head necrosis,distraction osteogenesis,etc.For the treatment of various orthopedic related diseases,Drynaria fortunei flavonoids can play a role through the same molecular protein pathway.From the microscopic point of view,this reflects the characteristic of traditional Chinese medicine of treating different diseases with the same therapeutic principle.Although drynaria fortunei flavonoids are widely used in basic and clinical fields,further research is needed to explore its mechanism of action,and the interaction between different molecular pathways needs further study and clarification.In addition,the total flavonoids of drynaria fortunei still belongs to mixed ingredients,among which naringin has a prominent function,but it cannot completely replace the function of total flavonoids of drynaria fortune.Therefore it is necessary to further separate and extract it,and identify different effective ingredients that regulate different targets of osteoporosis more accurately.