生物钟基因与骨免疫研究进展

Research progress on clock genes and osteoimmunology

昼夜节律是生命体为适应自然环境而产生的一种生物特性,生物钟基因调节着生命体的节律,Bmal1、Clock、PERs、CRYs、Rev-erbα等生物钟基因及下游的钟控基因发挥了重要作用。免疫细胞与骨细胞之间通过共同的细胞因子和信号通路相互作用,调节骨代谢平衡,免疫紊乱会导致骨代谢异常。骨免疫学的诞生有利于深入研究骨骼系统与免疫系统的相互作用,骨免疫参与了许多骨科疾病和免疫性疾病的发生和进展。生理状态下,生物钟基因通过调控骨骼系统与免疫系统的生物节律,在维持骨免疫的平衡状态中发挥着重要作用。病理状态下,生物钟基因功能异常不但导致骨骼系统和免疫系统的节律紊乱,进一步导致骨量丢失和免疫炎症反应,而且通过IL-1、IL-6、TNF-α、RANKL等骨免疫因子对骨代谢产生作用。反过来,免疫炎症反应也会对生物钟基因正常功能产生影响,进而影响骨代谢。根据生物钟基因和骨代谢自身的特点,认识生理病理状态下生物钟基因与骨免疫的相互作用,对骨骼系统疾病和免疫系统疾病的防治有一定的指导意义。

The circadian rhythm is a biological characteristic of living organisms in order to adapt to the natural environment.The clock genes such as Bmal1,Clock,PERs,CRYs,Rev-erbαand clock control genes exert vital function.The interaction between immune cells and bone cells regulates the balance of bone metabolism through the interaction of common cytokines and signaling pathways,and immune disorders could cause abnormal bone metabolism.The birth of osteoimmunology is beneficial to the further study of the interaction between skeletal system and immune system,and osteoimmunology is involved in the occurrence and progression of many orthopedic diseases and immune diseases.In the physiological state,clock genes play an important role in maintaining the balance of osteoimmunology by regulating the circadian rhythm of skeletal system and immune system.However,in the pathological state,clock genes malfunction not only causes the disorders of circadian rhythm of the skeletal system and the immune system,it further leads to loss of bone mass and immuno-inflammatory reactions.It also exerts effects on bone metabolism through osteoimmunology related factors such as IL-1,IL-6,TNF-αand RANKL.The immuno-inflammatory reactions also affect the normal function of clock genes,which in turn affects bone metabolism.According to the characteristics of clock genes and bone metabolism,understanding the interaction between clock genes and osteoimmunology under physiological and pathological conditions will have certain guiding significance for the prevention and treatment of skeletal system diseases and immune system diseases.