米诺环素联合甲硝唑药膜对牙周病患者牙周状况及炎症因子水平的影响

Influence of Minocycline combined with Metronidazole Film on periodontal status and inflammatory factors in patients with periodontal disease

目的探讨牙周病患者经米诺环素联合甲硝唑治疗后的炎症因子水平和牙周情况。方法选取我院2016年5月～2018年1月收治的98例牙周病患者作为研究对象,依照治疗方法的不同分为参照组(n=49)与研究组(n=49)。参照组采用盐酸米诺环素软膏治疗,研究组采用甲硝唑联合米诺环素治疗。比较两组的炎症因子水平、临床疗效率和牙周情况。结果参照组患者治疗后的IL-6和CRP等炎症因子水平与治疗前比较,差异无统计学意义(P>0.05)。研究组治疗后的IL-6水平与治疗前比较,差异无统计学意义(P>0.05),CRP水平显著低于治疗前,差异有统计学意义(P<0.05)。研究组患者治疗后的IL-6水平与参照组比较,差异无统计学意义(P>0.05);研究组患者的CRP水平显著低于参照组,差异有统计学意义(P<0.05)。研究组患者的临床疗效率为93.88%,高于参照组患者的77.55%,差异有统计学意义(P<0.05)。研究组患者的测定牙龈指数和牙周袋深度、牙龈出血指数和菌斑指数等牙周情况均低于参照组,差异有统计学意义(P<0.05)。结论对牙周病患者予以米诺环素联合甲硝唑治疗,其治疗效果良好,既能使炎症因子水平下降,还能使患者的牙周情况得到显著改善,对患者生活质量的提升能起到一定的促进作用。

Objective To investigate the level of inflammatory factors and periodontal status of periodontal disease patients treated with Minocycline combined with Metronidazole.Methods A total of 98 patients with periodontal disease admitted to our hospital from May 2016 to January 2018 were selected as the study subjects.According to the different treatment methods,they were divided into the reference group(n=49)and the research group(n=49).The control group was treated with Minocycline Hydrochloride Ointment,and the study group was treated with Metronidazole combined with Minocycline Hydrochloride Ointment.The levels of inflammatory factors,clinical efficacy rate and periodontal status of the two groups were compared.Results There was no statistically significant difference in the level of IL-6 and CRP between after treatment and before treatment in the control group(P>0.05).There was no statistical difference of IL-6 level after treatment compared with before treatment and CRP level in the study group after treatment was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in the level of IL-6 between the study group and the control group(P>0.05).After treatment,the CRP level of patients in the study group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The clinical efficacy rate of the patients in the study group was 93.88%,which was higher than that in the control group(77.55%),and the difference was statistically significant(P<0.05).The periodontal conditions such as gingival index,periodontal pocket depth,gingival bleeding index and plaque index in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment effect of Minocycline combined with Metronidazole in the treatment of patients with periodontal disease is good,which can not only make inflammatory factor levels drop,but also make periodontal condition of the patient markedly improved,it can play a certain role in promoting the quality of life of patients.