灯盏花素注射液联合单唾液酸神经节苷脂治疗周围性面瘫的效果

Effect of Breviscapine Injection combined with Monosialicganglioside on peripheral facial paralysis

目的探讨灯盏花素注射液联合单唾液酸神经节苷脂治疗周围性面瘫的效果。方法选取2015年1月～2017年12月我院收治的周围性面瘫患者90例,随机分为对照组(n=45)与观察组(n=45),观察组给予常规治疗+灯盏花素注射液联合单唾液酸神经节苷脂治疗,对照组给予常规治疗,比较两组患者的临床疗效和相关指标。结果观察组患者的总有效率显著高于对照组(P<0.05);两组患者治疗前的Portmann评分比较,差异无统计学意义(P>0.05),观察组患者治疗后7 d及2周的Portmann评分显著高于治疗前及对照组,差异均有统计学意义(P<0.05);两组患者治疗前的面神经波幅及面神经潜伏期比较,差异无统计学意义(P>0.05);观察组患者治疗后的面神经波幅显著高于治疗前,面神经潜伏期显著短于治疗前,差异均有统计学意义(P<0.05);观察组患者治疗后的面神经波幅显著高于对照组,面神经潜伏期显著短于对照组,差异均有统计学意义(P<0.05)。结论周围性面瘫患者采取灯盏花素注射液联合单唾液酸神经节苷脂治疗,疗效确切,具有临床推广价值。

Objective To explore the effect of Breviscapine Injection combined with Monosialicganglioside on peripheral facial paralysis.Methods Ninety patients with peripheral facial paralysis admitted to our hospital from January 2015 to December 2017 were randomly divided into control group(n=45)and observation group(n=45),the observation group was given routine treatment+Breviscapine Injection combined with Monosialoganglioside treatment,while the control group was given routine treatment.The clinical efficacy and related indicators of the two groups were compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in Portmann score between the two groups before treatment(P>0.05),the Portmann score of the observation group at 7 d and 2 weeks after treatment were significantly higher than that before treatment,and significantly higher than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the amplitude and latency of facial nerve between the two groups before treatment(P>0.05).After treatment,the amplitude of facial nerve wave in observation group was significantly higher than that before treatment,and the latency of facial nerve was significantly shorter than that before treatment,the differences were statitically signifscant(P<0.05).After treatment,the amplitude of facial nerve wave in the observation group was significantly higher than that in the control group,and the latency of facial nerve was significantly shorter than that in the control group,the differences were statitically signifscant(P<0.05).Conclusion Patients with peripheral facial paralysis were treated with Breviscapine Injection combined with Monosialoganglioside,the curative effect is definite and it has clinical value.