术前口服普瑞巴林对气管插管引起的血流动力学变化的影响

Effects of premedication with pregabalin on hemodynamic responses to laryngoscopy and tracheal intubation

目的:评估麻醉诱导前口服普瑞巴林胶囊抑制全麻诱导后气管插管所致血流动力学变化的效果。方法:2016年9月至12月连续纳入53例受试者,随机分为对照组和术前1h口服150mg普瑞巴林组(普瑞巴林组),其中对照组26例、普瑞巴林组27例。在服药前及服药后1h进行镇静程度评分(Ramsay评分);分别在服药前,气管插管前,气管插管后0、1、3、5、7、10min记录心率(heart rate,HR)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP),同时记录围手术期药物不良反应。结果:普瑞巴林组SBP、DBP在气管插管后1、3、5min均小于对照组(P<0.05);普瑞巴林组HR在气管插管后1min小于对照组(P<0.05)。普瑞巴林组Ramsay评分在服药后1h高于对照组(P<0.001)。两组患者围手术期不良反应的发生率差异无统计学意义。结论:术前口服150mg普瑞巴林可有效稳定气管插管后的血流动力学波动,降低术前焦虑程度,且不增加不良反应的发生。

Objective:To evaluate the effect of oral pregabalin capsules before anesthesia induction on hemodynamic changes induced by tracheal intubation after induction of general anesthesia.Methods:A total of 53 patients were included in the study during September 2016 and December 2016 consecutively.The patients were randomly assigned into two groups:26 patients in the control group and 27 patients in the pregabalin group(administrated 150 mg pregabalin orally 1 hour before surgery).The sedation grade(Ramsay score)was assessed before and one hour after medication.Heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)were recorded before medication,tracheal intubation,and 0,1,3,5,7,and 10 minutes after intubation.Perioperative adverse drug reactions were also recorded.Results:In the pregabalin group,the SBP and DBP at 1,3,and 5 minutes after tracheal intubation were lower than those in the control group(P<0.05).The HR of 1 minute after intubation showed significant difference from the control group(P<0.05).The Ramsay score was significantly higher in the pregabalin group than that in the control group at 1 hour after medication(P<0.001).There was no statistical difference in the incidence of perioperative adverse reactions between the two groups.Conclusions:Preoperative oral administration of 150 mg pregabalin can effectively attenuate the hemodynamic response after intubation and reduce the preoperative anxiety with no significant side effects.