Graves病甲状腺功能亢进症患者血清尿酸影响因素相关分析

Analysis of the Correlationship of Serum Uric Acid and the Related Factors in Patients with Hyperthyroidism in Grave's Disease

目的探讨在Graves病甲状腺功能亢进症(以下简称甲亢)患者中血清尿酸的相关影响因素。方法选取2016年5月～2017年5月上海长海医院内分泌科住院的163例Graves病甲亢患者为观察组,以同期门诊96例健康体检者为对照组,每组各分为男性组、女性(绝经前)组、女性(绝经后)组,比较相应组间血清尿酸的水平,采用Pearson线性相关性检验分析甲亢组血清尿酸水平与性别、年龄、体质指数(BMI)、甲状腺功能指标、空腹血糖、估算肾小球滤过率(e GFR)的相关性。结果甲亢组血清尿酸水平高于对照组(男性组383±95 vs 301±41,女性绝经前组342±69 vs 282±46,女性绝经后组330±106 vs 291±39μmol/L),甲亢组血清尿酸与性别相关(r=0. 443,P <0. 05),男性血清尿酸高于女性,甲亢组血清尿酸水平与年龄、BMI、血清TRAb呈正相关(r分别为0. 304、0. 427、0. 386,P <0. 05),血清尿酸水平与血清TSH呈负相关(r=-0. 395,P <0. 05)。结论Graves病甲亢患者的血清尿酸水平较正常人群高,与性别、年龄、BMI、血清TRAb及TSH相关,其中TRAb指标的相关性研究目前尚未见报道,在防治高尿酸血症时要针对患者的BMI、血清TRAb及TSH采取相应方案进行处置。

Objective To investigate the correlationship of serum uric acid and the related influencing factors in patients with hyperthyroidism in Grave′s disease Methods A total of 163 patients diagnosed with hyperthyroidism in Grave′s disease who were admitted to the endocrinology department of Shanghai changhai hospital from May 2016 to May 2017 were selected as the observation group.96 patients in the same period were selected as control group.Each group was divided into groups of men,women(premenopausal),women(post-menopausal)groups.The serum uric acid levels were compared in the corresponding groups.The linear Pearson correlation test analysis was used to analyze the correlationship of serum uric acid level and gender,age,body mass index(BMI),thyroid function and inflammatory index,fasting glucose,and estimated glomerular filtration rate(eGFR)in hyperthyroidism group.Results Serum uric acid levels in the hyperthyroidism group were higher than those in the control groups(men group 383±95 vs 301±41,women(premenopausal)group 342±69 vs 282±46,women(post-menopausal)group 330±106 vs 291±39μmol/L).Serum uric acid levels in hyperthyroidism group was correlated with gender(r=0.443,P<0.05).Serum uric acid levels of male were higher than those of female.Serum uric acid levels in hyperthyroidism group were positively correlated with age,BMI and serum TRAb(r=0.304,0.427,0.386,P<0.05).Serum uric acid levels were negatively correlated with serum TSH(r=-0.395,P<0.05).Conclusion Serum uric acid levels in the patients with hyperthyroidism in Grave′s disease were higher than those of normal people and correlated with gender,age,BMI,serum TRAb and TSH.The correlation of indicators of serum TRAb and uric acid has not been reported yet.These factors should be considered in the prevention and therapy of hyperuricemia and the patients′BMI,serum TRAb and TSH should be treated accordingly.