口腔鳞状细胞癌相关长链非编码RNA调控肿瘤细胞上皮-间充质转化的研究进展

Advances in long non-coding RNA regulation of epithelial-mesenchymal transition in oral squamous cancer

口腔癌是全球第6大常见恶性肿瘤,其侵袭和转移是导致患者死亡的首要原因。上皮-间充质转化(EMT)使上皮肿瘤细胞获得间充质表型,增强肿瘤细胞的迁移和侵袭能力,在肿瘤发生、发展和转移中发挥重要作用。近年来,越来越多的研究证明,长链非编码RNA(lncRNA)及其相关的信号通路网络已经成为肿瘤转移中诱导和调控EMT新的参与者。本文就涉及口腔癌EMT调节的几种lncRNA的最新研究进展进行综述。

Oral cancer is the sixth most common malignancy in the world,and its invasion and metastasis is the leading cause of death.Epithelial-mesenchymal transition(EMT)to epithelial tumour cells play an important role because they can obtain mesenchymal phenotype and enhance the migration and invasion of tumour cells in tumorigenesis,development and metastasis.In recent years,more and more studies have shown that long non-coding RNA(lncRNA)and its associated signalling pathways have become new participants in the induction and regulation of EMT in tumour metastasis.In this paper,the latest research of several lncRNAs involved in EMT regulation of oral cancer is reviewed.