石墨烯及其衍生物改性复合材料促成骨机制和应用的研究进展

Mechanism and application of osteogenesis induced by graphene and its derivatives modified composite materials

自体或异体骨移植是治疗骨缺损的有效方法,但仍存在感染、免疫排斥等问题。骨组织工程一直致力于通过不同材料诱导干细胞向成骨方向分化,以修复各种因素造成的骨缺损。将石墨烯及其衍生物负载在支架材料上能显著增强现有支架材料的生物相容性,并促进干细胞的黏附、增殖及成骨分化。本文对近年来石墨烯及其衍生物改性复合材料在成骨分化方面应用的研究进展进行综述,为石墨烯在骨组织工程中的应用提供新思路。

For a long time,autogenous bone graft is widely used in clinic and was verified to be effective in treating bone defects,but this technique is not perfect for the difficulty in healing of the donate site,immune rejection and infection.Bone tissue engineering approaches aims to aid the regeneration of bone tissues by filling the bone defects with different scaffolds which is able to induce the osteogenic differentiation of bone marrow stem cells.It is reported in former researches that graphene coating can significantly enhance the biocompatibility,cell adhesion and differentiation of scaffolds.In this review,we focused on the application of scaffolds modified with graphene and its derivatives to promote osteogenic differentiation published in recent years to providing new ideas for bone tissue regeneration.