血管因素与血管性认知功能损伤及痴呆

Effects of vascular factors on cognitive impairment and dementia

血管因素是诱导阿尔茨海默病等认知功能损伤的独立危险因素,其与认知功能损伤的相关机制复杂。针对导致认知功能损伤的相关血管因素进行深入研究,发现可干预治疗认知功能损伤的血管相关因素是目前干预痴呆进展的研究热点。血管损伤、缺血性卒中、免疫系统的激活、脑软膜的侧支循环、遗传和环境因素等是与血管性认知功能损伤相关的重要因素;另外基因突变、脂质代谢紊乱、血脑屏障等方面的进展,为发展新药物治疗认知功能损伤提供新的方向和措施。该文将总结血管因素在认知障碍中的相关机制及研究进展。

Vascular factors are independent risk factors for the induction of cognitive impairment such as Alzheimer′s disease,which is complicated with related mechanisms of cognitive impairment.Study on the related vascular factors that lead to cognitive impairment,finding correlation factors intervening to treat cognitive impairment are the hot spots in the study of the current development of dementia.Vascular injury,ischemic stroke,immune system activation,collateral circulation,heredity and environmental factors of the soft membrane are important factors related to vascular cognitive injury.In addition,advances in gene mutation,lipid metabolism disorder and blood-brain barrier have been developed to provide new directions and measures for the development of new drugs to treat cognitive impairment.This paper will summarize the mechanisms and research progress of vascular factors in cognitive disorders.