抑郁对晚期肺癌患者姑息治疗过程中生活质量的影响

Influence of depression on quality of life in advanced lung cancer patients with palliative care

目的探讨抑郁对晚期肺癌患者姑息治疗过程中生活质量的影响。方法通过调查2012年1月至2016年12月在奉贤区中心医院接受姑息治疗的88例晚期肺癌患者,采用抑郁自评量表(SDS)、生活质量核心问卷(QLQ-C30)和自行设计的一般情况问卷调查,了解晚期肺癌患者抑郁的发生情况,并分析抑郁对患者生活质量的影响。结果晚期肺癌老年患者姑息治疗过程中合并抑郁的发生率为52. 3%;与非抑郁组比较,抑郁组肺癌患者总体健康状况量表评分、功能量表评分明显降低,而症状量表评分、特异性条目评分均显著升高(P <0. 05);姑息治疗老年肺癌患者的总体健康状况量表评分在年龄、合并症等方面比较,差异有统计学意义(P <0. 05);多元线性回归分析显示,在控制性别、合并症、文化程度、家族史等因素后,年龄、SDS评分均是姑息治疗老年肺癌患者生活质量的独立危险因素(P <0. 05)。结论姑息治疗老年肺癌患者存在明显抑郁,整体生活质量水平较低,且抑郁严重影响患者的生活质量。

Objective To investigate the influence of depression on quality of life(QOL)in advanced lung cancer patients with palliative care.Methods 88 advanced lung cancer patients who received palliative care in our hospital from 2010.1 to 2016.12 were involved.Self-rating depression scale(SDS),QOL questionnare-core 30(QLQ-C30)and self-designed general condition questionnaire were used to record the incidence of depression,and its influence on QOL was analyzed.Results The incidence of depression in advanced lung cancer patients with palliative care was 52.3%.Compared with non-depression group,the scores of global quality of life,function scale were significantly decreased,while symptom score and specific items were significantly increased(P<0.05).There was significant difference on the global quality of life score between different ages,complications(P<0.05).Multiple linear regression analysis showed that,after controlling for gender,education level,complications,family history and other factors,age and SDS score were all independent risk factors for QOL in advanced lung cancer patients with palliative care(P<0.05).Conclusion Depression exists in advanced lung cancer patients with palliative care with low level of QOL,and depression is closely associated with QOL.