盐酸奥洛他定治疗慢性湿疹的临床疗效评价

Clinical efficacy of olopatadine hydrochloride in treatment of chronic eczema

(1)目的以氯雷他定片为对照,评价盐酸奥洛他定在治疗慢性湿疹症状方面的临床疗效。(2)方法 176例慢性湿疹患者按随机数字表法分为治疗组(n=89例)和对照组(n=87例)。治疗组口服盐酸奥洛他定片5mg,2次/d,对照组口服氯雷他定片10mg,1次/d,两组同时外用丙酸氟替卡松乳膏2次/d,在0、1、2、4周进行随访,每次随访均由同一个研究者根据湿疹面积及严重度指数评分法(EASI评分法)和瘙痒程度评分法对患者病情进行评估。(3)结果疗程结束后,治疗组和对照组显效率分别为88.8%和74.7%,差异有统计学意义(P <0.05);治疗组和对照组的不良反应发生率分别为10.11%和21.83%,差异有统计学意义(χ2=4.52,P <0.05)。(4)结论盐酸奥洛他定治疗慢性湿疹疗效较好,且安全性较高。

Objective To evaluate the effect of olopatadine hydrochloride and loratadine on chronic eczema.Methods A total of 176 outpatients with chronic eczema were randomly divided into two groups which were treated with olopatadine hydrochloride(treatment group,n=89)or loratadine(control group,n=87)respectively for 4 weeks.Results The apparent efficiency of the treatment group and the control group was 88.8%and 74.7%respectively,with statistically significant difference(P<0.05).The incidence of adverse reactions in the treatment group and the control group was 10.11%and 21.83%respectively,with statistically significant differences(χ2=4.52,P<0.05).Conclusion Olopatadine hydrochloride is a curative treatment of chronic eczema.