呋喃唑酮四联疗法10天疗程根除幽门螺杆菌疗效评价

Curative effect evaluation of furazolone in eradication of HP after 10 days of treatment

(1)目的评价呋喃唑酮四联疗法10天疗程根除幽门螺杆菌(HP)感染疗效及其安全性。(2)方法选取华北理工大学2017年4～10月经快速尿素酶试验或14 C呼气试验证实为HP阳性患者270例作为研究对象,随机数表法分为A组和B组。A组给予雷贝拉唑钠肠溶胶囊20mg、呋喃唑酮片100mg、枸橼酸铋钾胶囊0.6g、阿莫西林胶囊1.0g,2次/d,疗程10天。B组给予雷贝拉唑钠肠溶胶囊20mg、克拉霉素分散片0.5g、枸橼酸铋钾胶囊0.6g、阿莫西林胶囊1.0g,2次/d,疗程10天。两组均在停药4周后行14C呼气试验,观察两组HP根除情况、临床效果及不良反应发生率。(3)结果按照ITT分析,A组HP根除率为89.3%,B组为80.0%,两组比较差异有统计学意义(P <0.05)。按PP分析,A组HP根除率为92.6%,B组为83.9%,两组比较差异有统计学意义(P <0.05);A组临床症状缓解效果优于B组,差异有统计学意义(P <0.05)。两组均未出现难以耐受的不良反应,不良反应发生率差异无统计学意义(P>0.05)。(4)结论呋喃唑酮四联疗法10天疗程根除HP效果明显高于克拉霉素四联疗法,患者临床症状缓解效果增强,未增加不良反应,且成本低廉,是理想的根除方案。

Objective To evaluate the efficacy and safety of furazolidone in the eradication of HP after 10 days of treatment.Methods Selected 270 cases of HP-positive patients confirmed by rapid urease test or 14 C breath test from April to October 2017 in North China University of Science and Technology Affiliated Hospital,Random number table method was divided into group A and group B,Patients in group A were given rabeprazole sodium enteric-coated capsules(20mg),furazolidone tablets(100mg),bismuth potassium citrate(0.6g),and amoxicillin capsules(1.0g)twice a day for 10 days.Patients in group B were given 20mg of rabeprazole sodium enteric-coated capsules,clarithromycin dispersible tablets 0.5g,bismuth potassium citrate 0.6g and amoxicillin capsules 1.0g twice a day for 10 days.All groups were followed by a 14 C breath test 4 weeks after discontinuation of treatment.The rates of eradication,clinical effects and incidence of adverse reactions in the two groups were observed.Results According to ITT analysis,the eradication rate of HP in group A was 89.3%,and the eradication rate of HP in group B was 80.0%.There was significant difference between the two groups(P<0.05).According to PP analysis,the eradication rate of HP in group A was 92.6%,and the eradication rate of HP in group B was 83.9%.There was significant difference between the two groups(P<0.05).The clinical effect of group A was better than group B.The difference was statistically significant(P<0.05).No adverse reactions were found in both groups.There was no significant difference in the incidence of adverse reactions between group A and group B(P>0.05).Conclusion Furazolidone quadruple therapy for 10 days have a significantly higher eradication effect than the clarithromycin quadruple regimen,and enhanced the clinical symptoms relieving effect.The adverse reactions do not increase significantly,and the cost is low,which accords the ideal eradication plan.