中药防治化疗所致周围神经病变的研究进展

Research Progress of Traditional Chinese Medicine on Treatment of Peripheral Neuropathy

化疗致周围神经病变(CIPN)是肿瘤治疗后由化疗药物引起的神经毒性症状,目前没有FDA通过的可广泛用于临床的特效药物治疗,临床主要以止痛药对症治疗为主,辅以其他镇静药物,但效果不佳,甚至会导致抗肿瘤治疗失败。中医药防治该并发症有特定的优势且已证实具有一定的疗效,但仅限于小样本临床报道,实验研究较少且缺乏系统性。综述了中药对于化疗所致周围神经病变的研究及其机制,以期为CIPN的临床治疗提供依据和参考。

Chemotherapy induced peripheral neuropathy(CIPN)is chemotherapy drugs induced neurotoxicity occurred in anticancer treatment.Unfortunately,there is no specific clinical drug yet,only mainly symptomatic treatments with analgesics and sedative drugs are applied.CIPN can result in treatment delay,dose modification and termination of chemotherapy.Traditional Chinese medicine theory holds that CIPN is caused by arthromyodynia,previous study showed that Chinese medicine could effectively prevent the complications,but this is limited to clinical reporting,and also lacks support of sufficient evidence and system study.This Review provides a crucial update of the pathogenesis of CIPN and related signaling pathway with Chinese medicine treatment.It will provide a basic reference for the clinical treatment of CIPN.