苯妥英钠制备工艺的改进

Improvement of Preparation Technology of Phenytoin Sodium

在苯妥英钠制备过程中,以维生素B1盐酸盐代替氰化物做催化剂进行安息香缩合,以三价铁离子代替浓硝酸为氧化剂制备二苯乙二酮,对苯妥英钠制备工艺进行改进,改进后的制备工艺具有操作简单、污染低、收率高、产品质量好等优点,具有很好的工业化前景。

Benzoin was synthesized by benzoin condensation using vitamin B1 hydrochloride instead of cyanide as catalyst and ferric ion instead of concentrated nitric acid as oxidant in the preparation of phenytoin sodium.It has good quality and good industrial prospects.