强迫症认知行为治疗的神经影像学研究(综述)

A review of neuroimaging study of cognitive behavioral therapy for obsessive-compulsive disorder

本文回顾了强迫症患者认知行为治疗前后脑变化的神经影像学研究,分别从强迫症患者认知行为治疗前后脑功能、脑代谢及脑结构三方面进行了阐述,认知行为治疗可能是通过减弱眶额回、前扣带回的功能,增加N-乙酰天门冬氨酸的浓度及减少眶额回灰质体积的生物学机制来改善强迫症状,为其临床治疗提供依据。

This paper reviews the neuroimaging studies pre-and post-the cognitive behavioral therapy,from brain function,neurochemistry and structure respectively,in obsessive-compulsive disorder,to explore the neurobiological mechanism of cognitive behavioral therapy.Results show that cognitive behavioral therapy can improve clinical symptoms through decreasing the activity in orbitofrontal gyrus and anterior cingulate cortex,increasing the N-acetylaspartate concentration and reducing the orbital frontal gray matter volume,which will provide the evidences for clinical therapy.