环状RNA在肿瘤放射治疗中的研究展望

Research progress of circular RNA and its research prospects in tumor radiotherapy

肿瘤细胞放射性抵抗是目前抗癌治疗中难以解决的一大难点,但其抵抗的分子机制至今尚不明确。环状RNA(circRNA)是真核生物内的一类封闭环形RNA分子,具有组织特异性、稳定性和易于检测等特点,与肿瘤的早期诊断和放疗抵抗密切相关。circRNA能发挥微小RNA(miRNA)海绵吸附作用,调控与肿瘤放疗抵抗相关的miRNA和信号转导通路,使其有望成为提高肿瘤放疗敏感性的新型生物标记物及治疗靶点。本文综述了circRNA的研究进展,并展望其在肿瘤放射治疗应用中的研究前景。

Currently,radioresistance is one of the most difficult problems in the cancer treatment and its molecular mechanisms are still not well documented.Circular RNAs are a species of RNAs with closed loop structure in eukaryote,characterized by its tissue specificity,stability and easy detection.And it is closely associated with the cancer early diagnosis and radioresistance.Circular RNAs can serve as miRNA sponges to modulate the microRNAs and signal pathways of tumor radioresistance.Therefore,circular RNAs may be expected to be a novel type of biomarkers and therapeutic targets for enhancing the radiosensitivity of tumor.Here,we reviewed the research progress of circular RNAs and discussed its research prospects in tumor radiotherapy.