弓形虫感染与阿尔茨海默病相关性的研究进展

Advances on the association between Toxoplasma gondii infection and Alzheimer's disease

阿尔茨海默病(Alzheimers disease,AD)是老年人常见的一种中枢神经系统退行性疾病,AD的发病机制尚未完全阐明。多项研究发现:AD患者血清弓形虫抗体阳性率高于对照组;弓形虫感染可诱发或加重认知障碍、记忆进行性减退等AD样症状;弓形虫感染引起脑组织Aβ沉积、Tau蛋白高度磷酸化和神经元损伤等AD样病变。研究结果提示弓形虫感染与AD具有关联性。本文就弓形虫感染与AD相关性的研究进展做一综述。

Alzheimer s disease(AD)is a progressive neurodegenerative disease,and the pathogenesis of AD has not been fully elucidated.Patients with AD had higher seropositivity rates for anti-Toxoplasma gondii(T.gondii)IgG antibodies compared to healthy controls.T.gondii infection caused AD-like symptoms(cognitive impairment,memory loss);infected wild-type mice showed major signs of AD including Aβdeposition,pTau expression,and neuronal loss.Results of researches indicate a possible link between T.gondii infection and AD.In this review,we summarized recent advances on the association between T.gondii infection and AD.