二维超声检测孕16～40周胎儿胆囊大小参考值范围

Reference range of fetal gallbladder size from 16 to 40 weeks by 2D ultrasound

目的建立二维超声孕16~40周胎儿胆囊大小的参考值范围,探讨胎儿胆囊二维测值与孕周的关系,为产前检查提供评价胎儿生长发育的新指标。方法纳入2014年12月~2017年8月于我院行产前筛查的孕13~40周、单胎、孕妇无妊娠并发症、孕妇在成都地区生活时间>5年的721例胎儿,观察胎儿胆囊显示情况,纳入能清晰显示胎儿胆囊的684例胎儿,测量胆囊纵径、前后径,获得胎儿胆囊生长曲线及方程。结果正常胎儿胆囊纵径及前后径大小与孕周呈直线线性相关,相关方程为纵径:Y=0.347X+12.481 (X=孕周,Y=胆囊长径),P<0.01,R2=0.092;前后径:Y=0.056X+3.222(X=孕周,Y=胆囊前后径),P<0.01,R2=0.043,根据方程可得出相应孕周的正常值参考范围。结论二维超声测量胎儿胆囊大小能够一定程度评估胎儿发育情况,尤其是胎儿胆道系统发育情况;二维测值以胆囊纵径评估较准确,通过对胎儿胆系的观察可为诊断胎儿胆系异常提供有价值的信息。

Objective To establish the reference range of 2D measurement of fetal gallbladder at 16-40 weeks gestational,get the growth curve and equation of fetal gallbladder,compare with the existing reference values of other regions and explore the relationship between fetal gallbladder a new indicator of fetal growth and development for prenatal care.Methods 721 fetal form Chengdu First People's Hospital form December 2014 to August 2017 were selected in the present study.The fetal were 13 to 40 weeks,single pregnancy and the pregnant women without complications.The longitudinal and anteroposterior diameter of the gallbladder were measured.Results The longitudinal and anteroposterior diameter of normal fetal gallbladder was linearly correlated with gestational weeks.The correlation equation was longitudinal diameter:Y=0.347X+12.481(X=gestational weeks,Y=long diameter of gallbladder),P<0.01,R2=0.092;anteroposterior diameter:Y=0.056X+3.222(X=gestational weeks,Y=gallbladder anteroposterior diameter),P<0.01,R2=0.043.The equation can be derived from the normal gestational week reference range.Conclusion The 2D measurement of fetal gallbladder can assess fetal development to a certain extent,especially fetal biliary system development.2D measurement of gallbladder longitudinal length of the assessment is more accurate,through the observation of fetal gall bladder can be diagnosed for fetal biliary abnormalities Valuable information.