小细胞肺癌患者血清NSE水平与TNM分期的关系及对患者预后的影响

The Relationship between Serum NSE Level and TNM Staging in Patients with Small Cell Lung Cancer and Its Effect on the Prognosis of Patients

目的探讨小细胞肺癌患者血清神经元特异性烯醇化酶(NSE)水平与TNM分期的关系及对患者预后情况的影响。方法采用电化学发光免疫法对97例小细胞肺癌患者血清NSE水平进行检测,比较不同TNM分期小细胞肺癌患者的血清NSE水平,分析小细胞肺癌患者的血清NSE水平与TNM分期之间的相关性,并采用单因素分析小细胞肺癌患者的预后影响因素。结果随着小细胞肺癌患者TNM分期的增加,患者的血清NSE水平明显升高(P <0. 05),小细胞肺癌患者的血清NSE水平与TNM分期之间呈明显的正相关性(γ=0. 573,P=0. 000);血清NSE水平、PS评分以及TNM分期均为影响小细胞肺癌患者生存的因素(P <0. 05)。结论小细胞肺癌患者的血清NSE水平与临床TNM分期之间呈明显的正相关性。血清NSE水平、PS评分以及TNM分期均为影响小细胞肺癌患者生存的因素,对患者手术治疗效果和预后评估具有重要的临床价值。

Objective To investigate the relationship between serum NSE level and TNM staging in patients with small cell lung cancer and its effect on the prognosis of patients.Methods Selected 97 cases of patients with small cell lung cancer.The serum NSE level was detected by electrochemiluminescence immunoassay.The serum NSE levels of patients with small cell lung cancer at different TNM stages were compared,and the correlation between serum NSE level and TNM staging was analyzed,and the prognostic factors of patients with small cell lung cancer were analyzed by single factor analysis.Results With the increase of TNM stage in the patients with small cell lung cancer,the serum NSE level of the patients significantly increased(P<0.05).There was a significant positive correlation between serum NSE level and TNM staging in small cell lung cancer patients(γ=0.573,P=0.000).The serum NSE level,PS score and TNM staging were all prognostic factors affecting the survival of the patients with small cell lung cancer(P<0.05).Conclusion The level of serum NSE in patients with small cell lung cancer and clinical TNM staging showed a positive correlation,and the level of serum NSE,PS score and TNM stage are prognostic factors for survival in patients with non-small cell lung cancer,it has important clinical value to evaluate the therapeutic effect and prognosis of patients.