血清肿瘤坏死因子表达水平与妊娠合并甲状腺功能减退的关系

The Study of Correlation between Serum Tumor Necrosis Factor-alpha and Hypothyroidism in Pregnancy

目的研究血清肿瘤坏死因子-α(TNF-α)水平与妊娠期合并甲状腺功能减退的关系。方法选取86例妊娠期合并甲状腺减退患者为研究对象(观察组),另选同期健康体检孕妇86例为对照组。观察组采用优甲乐进行治疗。治疗前后空腹采集2组研究对象的静脉血,采用贝克曼TOP-500检测促甲状腺素(TSH)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4); ELISA法检测TNF-α。对2组检测结果进行比较分析。结果治疗前观察组血清TNF-α、TSH高于对照组,T3、T4、FT3、FT4低于对照组,差异均有统计学意义(P <0. 05)。治疗后与治疗前相比,观察组TSH和TNF-α降低,T3、T4、FT3、FT4升高,差异具有统计学意义(P <0. 05);与对照组相比,差异均无统计学意义(P> 0. 05)。相关性分析表明TNF-α与TSH呈正相关(γ=0. 9044,P <0. 01)。结论优甲乐治疗妊娠期合并甲状腺功能减退有效,TNF-α水平升高与妊娠期合并甲状腺功能减退存在相关。

Objective To investigate the correlation between serum tumor necrosis factor-alpha and hypothyroidism in pregnancy.Methods 86 patients with hypothyroidism in pregnancy were selected as the observation group.86 healthy cases were selected as the control group.The observation group was treated with euthyrox.The venous blood was collected from the 2 groups before and after treatment.ELISA was employed to test concentration of TNF-α.Beckman TOP-500 synchron clinical system was used to detect the concentration of TSH、triiodothyronine(T3)、thyroxine(T4)、free triiodothyronine(FT3)、free thyroxine(FT4).Then the levels of TSH,T3,T4,FT3,FT4 of two groups after treatment were compared.Results Before the treatment,the level of TNF-α,TSH in the observation group was higher than the control group,the levels of T3、T4、FT3、FT4 was lower than the control group(P<0.05).The level of TSH and TNF-αwere significantly lower,the T3,T4,FT3,FT4 were higher as compared with that before treatment(P<0.05).there was no different compared with the control group(P>0.05).relevant analysis result showed the relationship was highly significant positive between TNF-αand TSH(γ=0.9044,P<0.01).Conclusion Euthyrox is well for hypothyroidism during pregnancy,serum tumor necrosis factor-alpha is associated with hypothyroidism during pregnancy.