摘要
目的研究榄香烯注射液联合吉西他滨+顺铂(GP)化疗方案治疗晚期非小细胞肺癌的临床疗效及安全性。方法随机选取100例晚期非小细胞癌,并采用随机抽样法将患者分为对照组和观察组,各50例。对照组患者采用GP化疗方案,观察组在对照组治疗的基础上联合榄香烯注射液治疗。观察患者的治疗效果、生存率、生存质量及安全性。结果观察组的总有效率为90. 0%(45/50),明显高于对照组的78. 0%(39/50)(P <0. 05)。6个月时,2组患者的生存率无明显差异(P> 0. 05); 12、24个月时,观察组的生存率明显高于对照组,且观察组的中位生存期明显长于对照组(P <0. 05)。治疗过程中,观察组的骨髓抑制、血红蛋白减少及肝肾功能损伤的发生率明显低于对照组(P <0. 05)。治疗前,2组患者呼吸困难、食欲减退、咳嗽、咯血及疼痛无明显差异(P> 0. 05);治疗后,2组患者的呼吸困难、食欲减退、咳嗽、咯血及疼痛评分降低,但观察组呼吸困难、食欲减退、咳嗽、咯血及疼痛评分高于对照组(P <0. 05)。结论榄香烯注射液联合GP化疗方案治疗晚期非小细胞肺癌,能提高疗效,改善患者生活质量及降低不良反应发生率,值得临床借鉴参考。
Objective To study the clinical efficacy and safety of Elemene Injection combined with Gemcitabine+cisplatin(GP)chemotherapy in the treatment of advanced non-small cell lung cancer.Methods 100 cases of advanced non small cell carcinoma were admitted were randomly selected.The patients were randomly divided into the control group and the observation group,50 cases in each group.The control group were treated with GP chemotherapy.The observation group was treated with Elemene Injection on the basis of the control group.The treatment effect,survival rate,quality of life evaluation and safety evaluation were counted.Results The total effective rate was 90.0%(45/50)in the observation group,significantly higher than that of the control group 78.0%(39/50)(P<0.05).After 6 months,there was no significant difference in the survival rate between the 2 groups(P>0.05).The survival rate in the observation group was significantly higher than that of the control group after 12 and 24 months,and the median survival time in the observation group was significantly higher than that of the control group(P<0.05).During the treatment,the bone marrow suppression,hemoglobin reduction and liver and kidney function damage rate in the observation group were significantly lower than those of the control group(P<0.05).Before treatment,2 groups of patients with anorexia,dyspnea,cough,hemoptysis and pain had no significant difference(P>0.05);after treatment,the 2 groups of patients with anorexia,dyspnea,cough,hemoptysis and pain scores decreased,but the observation group anorexia,dyspnea,cough,hemoptysis and pain scores were higher than that of the control group(P<0.05).Conclusion Elemene Injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer can increase the curative effect,improve the quality of life and safety index of treatment,which is worthy of clinical reference.
作者
徐建林
郑瑞锋
王彦威
XU Jianlin;ZHENG Ruifeng;WANG Yanwei(He'nan General Hospital of Armed Police,Zhengzhou,450052)
出处
《实用癌症杂志》
2018年第11期1878-1881,共4页
The Practical Journal of Cancer