脑白质疏松患者肾功能异常的相关因素分析

Analysis of related factors of renal dysfunction in patients with leukoaraiosis

目的探讨脑白质疏松(LA)患者肾功能异常的相关因素及其可能的机制。方法收集2016年12月至2017年6月于河北医科大学第二医院神经内科住院的451例LA患者,依据其肾功能水平分为两组:肾功能异常组(观察组)126例,肾功能正常组(对照组)325例。记录两组的一般资料及临床常见的可能危险因素,进行Logistic回归分析。结果 451例LA患者中,肾功能异常的发病率为27.94%,Logistic回归分析显示年龄(OR=1.026,95%CI:1.002-1.051,P=0.034)、同型半胱氨酸(Hcy)(OR=1.019,95%CI:1.001-1.037,P=0.042)、超敏C反应蛋白(hs-CPR)(OR=1.009,95%CI:1.002-1.017,P=0.019)差异有统计学意义(P<0.05),是LA患者肾功能异常的独立危险因素。结论年龄、血Hcy、hs-CRP参与LA患者肾功能异常的发病机制,对LA患者应当积极监测控制血Hcy、hs-CRP,以防治其肾功能的损害。

Objective To explore the related factors and the potential mechanism of renal dysfunction in patients with leukoaraiosis(LA).Method 451 cases of LA during from December 2016 to June 2017 were analyzed from the Second Hospital of Hebei Medical University,which were divided into two groups according to the renal function,renal dysfunction group(observation group)cases of 126 cases,normal renal function group(control group)cases of 325 cases.We proceeded the Logistic regression analysis after collectting the general data and the possible risks of the two groups.Results The incidence rate of renal dysfunction was 27.94%in 451 LA cases,Logistic regression analysis showed that the age(OR=1.026,95%CI:1.002-1.051,P=0.034),the homocysteine(Hcy,OR=1.019,95%CI:1.001-1.037,P=0.042)and the high sensitivity C-reactive protein(hs-CPR,OR=1.009,95%CI:1.002-1.017,P=0.019)were statistically significant(P<0.05),and were independent risks of renal dysfunction in LA.Conclusion The age,Hcy and hs-CRP are involved in the pathogenesis of renal dysfunction in LA.Full atendent should be paid to monitor and control the level of Hcy and hs-CRP of LA in order to prevent the damage of renal function.