特利加压素联合人血白蛋白治疗肝硬化顽固性腹水的临床疗效观察

Clinical observation of terlipressin with human albumin in the treatment of cirrhosis with refractory ascites

目的探讨特利加压素联合人血白蛋白治疗肝硬化顽固性腹水的临床疗效。方法我院收治的232例肝硬化顽固性腹水患者,按照随机数字表法分为观察组(n=121)和对照组(n=111)。对照组给予常规治疗,观察组在常规治疗的基础上加用特利加压素治疗,观察两组患者的临床疗效。结果治疗后两组临床表现包括腹围、心率和24小时尿量,生化指标包括人血白蛋白、肌酐、尿钠排出量和凝血酶原时间均较治疗前明显改善(P <0. 05)。观察组腹围、心率和24小时尿量及人血白蛋白、肌酐和尿钠排出量等指标改善程度优于对照组;凝血酶原时间改善总有效率高于对照组(P <0. 05)。结论特利加压素联合人血白蛋白对肝硬化顽固性腹水患者的临床治疗效果更好,患者临床症状改善程度更明显,值得临床广泛应用。

To investigate the clinical efficacy of terlipressin combined with human albumin in the treatment of cirrhosis with refractory cirrhosis ascites.Two hundred and thirty-two patients with refractory cirrhosis ascites of liver cirrhosis in our hospital were randomly divided into observation group(n=121)and control group(n=111).The control group was given routine treatment while the observation group was given terlipressin based on the routine treatment.The clinical efficacy was compared between the two groups.After treatment,the clinical manifestations including abdominal circumference,heart rate,24-hour urine volume and biochemical indexes such as human albumin,creatinine,urinary sodium excretion and prothrombin time were significantly improved in the two groups(P<0.05).The improvements in the observation group were significantly better than those in the control group(P<0.05).The total effective rate of prothrombin time improvement in the observation group was significantly higher than that in control group(P<0.05).Terlipressin combined with human albumin in the treatment of patients with refractory ascites of cirrhosis has better clinical effect.Clinical symptoms of the patients are improved more significantly.It is worthy of wide clinical application.