牙周炎与高脂血症的相关性研究

Correlation between Periodontitis and Hyperlipidemia

目的:探究牙周炎与高脂血症是否存在相关性。方法:收集重度慢性牙周炎患者和健康志愿者的血清,测定其胆固醇、三酰甘油、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇的浓度,并研究牙周基础治疗对血脂指标的影响。另外,分别通过高脂饮食和牙周结扎建立高脂血症和牙周炎大鼠模型,测定其血脂水平。最后,利用流式细胞术分析CD3、CD4和CD8在大鼠牙周组织细胞中的表达。结果:重度慢性牙周炎患者血脂水平与健康组比较差异无统计学意义。牙周基础治疗对重度牙周炎合并高脂血症患者血脂水平无显著影响。流式细胞术结果证实,单纯高脂饮食组大鼠牙周组织T细胞较空白对照组显著高表达CD3、CD4和CD8。结论:牙周炎不会导致高脂血症,但高脂血症可以促进牙周炎的发生。

Objective:To explore the relationship between periodontitis and hyperlipidemia.Method:The serum from severe chronic periodontitis patients and healthy volunteers was gathered and tested the concentrations of cholesterol,triglycerides,high density lipoprotein,and low density lipoprotein.The influence of periodontal basic treatment for the blood lipid levels was researched.In addition,the rat experimental hyperlipoidemia and periodontitis models were established by high fat diet and periodontal ligation,whose blood lipid levels and expression of CD3,CD4,and CD8 in the periodontal tissue cells were detected by flow cytometry.Result:The blood lipid levels of severe chronic periodontitis patients were similar to that of health volunteers.The levels of cholesterol,triglycerides,high density lipoprotein,and low density lipoprotein of patients with severe periodontitis and hyperlipidemia were not significantly changed after periodontal basic treatment for 3 months.The results of this clinical test were further validated by animal experiments.The expression proportion of CD3+,CD4+,and CD8+T cells in the simple hyperlipidemia group were higher than that of blank control group.Conclusion:Periodontitis does not cause hyperlipidemia,but hyperlipidemia can promote periodontitis.