罗汉果甜苷降糖机制及生物合成研究进展

Hypoglycemic Mechanisms and Biosynthesis of Mogrosides from Siraitia grosvenorii Fruit:A Review

甜苷是罗汉果中具有降糖作用的葫芦烷三萜类化合物,其血糖调节机制复杂,迄今尚未完全阐明。此外,甜苷含量低,通过对甜苷合成代谢中关键酶的克隆与功能表征有效增加其产量。本文综述了罗汉果甜苷的降糖机制及分子合成途径,探讨了当前研究所面临的问题,以期为甜苷的药物开发和生物合成研究提供参考。

Mogrosides are components of cucurbitane triterpenes,have hypoglycemic activity,and are found in the fruit Siraitia grosvenorii.The mechanism by which mogrosides reduced blood sugar was complex and needed to be interpreted;in addition,there was a problem of low content of mogrosides in Siraitia grosvenii,and biosynthesis was an attractive way to produce mogrosides on a large scale.In terms of biosynthesis of mogrosides,the key enzymes have been cloned and expressed,which provided the basis for mogroside synthesis and the establishment of cell factories.In this paper,the hypoglycemic effect and the progress of the biosynthesis mechanism of mogrosides was reviewed,which provided the reference for advancing the development and biosynthesis of mogrosides.