摘要
巨噬细胞作为固有免疫系统中的重要一员,具有吞噬、抗原呈递、杀伤病原体等功能,在早期控制病原菌感染中发挥重要作用。病原菌可诱导巨噬细胞发生M1/M2型极化而参与机体对病原菌感染的免疫应答。病原菌运用不同的策略诱导巨噬细胞极化,对感染性疾病转归产生重要的影响。
Macrophages,an important member of the innate immune system,have the functions of phagocytosis,antigen presentation and pathogen killing and play an important role in the early control of pathogen infection.Pathogen can induce M1/M2 macrophages polarization and participate in the body′s immune response to pathogen infection.Pathogens use different strategies to induce macrophage polarization and have an important impact on the outcome of infectious diseases.
作者
张焱皓
龙润莹
刘旭恒
刘芊伊
李茂
罗军敏(指导教师)
ZHANG Yan-Hao;LONG Run-Ying;LIU Xu-Heng;LIU Qian-Yi;LI Mao;LUO Jun-Min(Department of Immunology,Zunyi Medical College,Immune Molecules Application Research Center in Guizhou Province,Zunyi 563003,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2018年第11期1748-1752,1761,共6页
Chinese Journal of Immunology
基金
本文为国家自然科学基金地区项目(81460249,81860291)
贵州省科学技术厅科技计划项目(黔科合基础[2018]1192)。
关键词
巨噬细胞
极化
病原菌
Macrophage
Polarization
Pathogen
