瓜氨酸化在多发性硬化中的机制探究

Citrullination in mechanism of multiple sclerosis

多发性硬化(MS)是全球分布的中枢神经系统(CNS)自身免疫性脱髓鞘疾病,目前认为其发病是基因易感性与环境因素双重作用的结果。瓜氨酸化是一种可在正常代谢中观察到的转录后修饰,但是异常的瓜氨酸化可以转变自身抗原表位而激发自身免疫异常导致的自身免疫性疾病。近期关于EB病毒(EB)感染与自噬在多发性硬化发病机制相关联系的研究中发现抗原瓜氨酸化在免疫异常触发中的重要作用。本文就瓜氨酸化在多发性硬化病理机制中的作用进行综述,以期了解二者相互联系的意义。

Multiple sclerosis is a kind of global distributed CNS disease,thoughted resulted by genotype-environment interaction.Citrullination is a kind of post-translational modification can be detected in normal metabolism,but uncontroled citrullination may induce ectopic immune even autoimmune diseases.A resent study about EBV infection and autophagy with MS mentioned the important role of citrullinated peptides in the failurs on immune.We will discuss the role of citrullination in the pathomechanism of MS,inquiring the relation betweent them.