摘要
AIM: To determine whether evidential value exists that exercise reduces depression in adults with arthritis and other rheumatic conditions.METHODS: Utilizing data derived from a prior metaanalysis of 29 randomized controlled trials comprising 2449 participants(1470 exercise, 979 control) with fibromyalgia, osteoarthritis, rheumatoid arthritis or systemic lupus erythematosus, a new method, P-curve, was utilized to assess for evidentiary worth as well as dismiss the possibility of discriminating reporting of statistically significant results regarding exercise and depression in adults with arthritis and other rheumatic conditions. Using the method of Stouffer, Z-scores were calculated to examine selective-reporting bias. An alpha(P) value < 0.05 was deemed statistically significant. In addition, average power of the tests included in P-curve, adjusted for publication bias, was calculated. RESULTS: Fifteen of 29 studies(51.7%) with exercise and depression results were statistically significant(P < 0.05) while none of the results were statistically significant with respect to exercise increasing depression in adults with arthritis and other rheumatic conditions. Right-skew to dismiss selective reporting was identified(Z =-5.28, P < 0.0001). In addition, the included studies did not lack evidential value(Z = 2.39, P = 0.99), nor did they lack evidential value and were P-hacked(Z = 5.28, P > 0.99). The relative frequencies of P-values were 66.7% at 0.01, 6.7% each at 0.02 and 0.03, 13.3% at 0.04 and 6.7% at 0.05. The average power ofthe tests included in P-curve, corrected for publication bias, was 69%. Diagnostic plot results revealed that the observed power estimate was a better fit than the alternatives. CONCLUSION: Evidential value results provide additiona support that exercise reduces depression in adults with arthritis and other rheumatic conditions.
AIM: To determine whether evidential value exists that exercise reduces depression in adults with arthritis and other rheumatic conditions.METHODS: Utilizing data derived from a prior metaanalysis of 29 randomized controlled trials comprising 2449 participants(1470 exercise, 979 control) with fibromyalgia, osteoarthritis, rheumatoid arthritis or systemic lupus erythematosus, a new method, P-curve, was utilized to assess for evidentiary worth as well as dismiss the possibility of discriminating reporting of statistically significant results regarding exercise and depression in adults with arthritis and other rheumatic conditions. Using the method of Stouffer, Z-scores were calculated to examine selective-reporting bias. An alpha(P) value < 0.05 was deemed statistically significant. In addition, average power of the tests included in P-curve, adjusted for publication bias, was calculated. RESULTS: Fifteen of 29 studies(51.7%) with exercise and depression results were statistically significant(P < 0.05) while none of the results were statistically significant with respect to exercise increasing depression in adults with arthritis and other rheumatic conditions. Right-skew to dismiss selective reporting was identified(Z =-5.28, P < 0.0001). In addition, the included studies did not lack evidential value(Z = 2.39, P = 0.99), nor did they lack evidential value and were P-hacked(Z = 5.28, P > 0.99). The relative frequencies of P-values were 66.7% at 0.01, 6.7% each at 0.02 and 0.03, 13.3% at 0.04 and 6.7% at 0.05. The average power ofthe tests included in P-curve, corrected for publication bias, was 69%. Diagnostic plot results revealed that the observed power estimate was a better fit than the alternatives. CONCLUSION: Evidential value results provide additiona support that exercise reduces depression in adults with arthritis and other rheumatic conditions.
基金
Supported by The National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health(GAK,Principal Investigator),No.RO1AR061346
the National Institute of General Medical Sciences of the National Institutes of Health,No.U54GM104942
