血清转氨酶对急性冠脉综合征患者PCI术后生存状况的影响

Effect of serum transaminase on survival of patients with acute coronary syndrome after PCI

目的探讨血清转氨酶对急性冠脉综合征患者经皮冠状动脉介入治疗(PCI)术后生存状况的影响。方法选取2013年4月-2017年1月胸科医院因急性冠脉综合征(ACS)行PCI治疗的符合条件的冠心病患者315例作为研究对象。分为死亡组45例,对照组270例。结果两组年龄、心率(HR)、收缩压(SBP)、舒张压(DBP)及体重比较,差异有统计学意义(P<0.05);两组总胆固醇(TC)、三酰甘油(TG)水平比较,差异无统计学意义(P>0.05);与死亡者比较,两组白蛋白、血红蛋白(Hb)、尿素、肌酐(Cr)、尿酸(VA)、C反应蛋白(CRP)、肌酸激酶-MB、γ-谷氨酰转肽酶、丙氨酸转氨酶及门冬氨酸转氨酶水平比较,差异有统计学意义(P<0.05);通过多因素非条件logistic回归模型分析,发现患者年龄、HR、尿素、Cr、VA、CRP、肌酸激酶-MB、γ-谷氨酰转肽酶、丙氨酸转氨酶及门冬氨酸转氨酶水平是死亡的影响因素(P <0.05),与白蛋白、血红蛋白呈负相关。结论血清转氨酶升高是影响患者PCI术后生存状况的因素之一,预示着较高的死亡率。

Objective To investigate the effect of serum transaminase on the survival of patients with acute coronary syndrome after PCI.Methods Totally 315 patients with coronary heart disease(CHD)who underwent PCI in our hospital from April 2013 to January 2017 were selected as the subjects.A total of 45 dead patients were in the death group and other 270 cases were in control group.Several follow-up assessments were performed with retrospective analysis.Results Compared with the control group,age,heart rate,systolic blood pressure,diastolic blood pressure and body weight were statistically significant in death group(P<0.05).There was no significant difference in the level of total cholesterol and triglyceride between the two groups(P>0.05).Compared with the death group,albumin,hemoglobin,urea,creatinine,uric acid,C reactive protein,creatine kinase-MB,gamma glutamyl transpeptidase,alanine aminotransferase and aspartate aminotransferase levels were statistically significant in control group(P<0.05).Age,heart rate,urea,creatinine,uric acid,C reactive protein,creatine kinase-MB,patients with gamma glutamyl transpeptidase,alanine aminotransferase,aspartate aminotransferase levels were positively correlated with death,while were negatively correlated with albumin and hemoglobin.Conclusions Elevation of serum transaminase is one of the factors that affects the survival status of PCI patients,which indicates a higher mortality rate.