肿瘤标志物检测方法研究进展

Research progress in the determination methods of tumor markers

肿瘤是威胁人类健康的重大疾病,发病率、死亡率逐年升高。肿瘤标志物由肿瘤组织或宿主对肿瘤的反应产生,能够反映和监测肿瘤的发生、发展,判断肿瘤的预后和复发。肿瘤的早期检出具有重要意义。监测肿瘤标志物水平变化是评估肿瘤治疗效果的重要方法,常见的肿瘤标志物检测方法有免疫学方法、生物传感器、蛋白组学技术、分子生物学方法、液体活检等。不同的肿瘤标志物检测方法具有各自不同的特征,文章对几种常见肿瘤标志物检测方法的研究进展作一综述。

Tumor is a serious hidden threat to human health,and the morbidity and mortality rates of the diseases caused by tumors are increasing year by year.Tumor markers are produced by tumor tissues or their host reacts,which can reflect and monitor the occurrence,development,prognosis and recurrence of tumors.Early determination of tumors is important,and monitoring the change of tumor markers is also an important method to evaluate the therapeutic effect of tumors.The common determination methods of tumor markers include immunology,biosensor,proteomics,molecular biology,liquid biopsy and so on.Different determination methods of tumor markers have different characteristics.This review focuses on the research progress of several common determination methods of tumor markers.