摘要
During the last years increasing evidence implies that human cytomegalovirus(CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.
During the last years increasing evidence implies that human cytomegalovirus(CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.
基金
Supported by Grants from Ragnar Soderbergs Foundation
The Swedish Children’s Cancer Foundation
BILTEMA Foundation
Family Ehring Perssons Foundation
Sten A Olssons Foundation
Stichting af Jochnicks Foundation
The Swedish Cancer Society,The Swedish Research Council,the Marta and Gunnar V Philipson Foundation
The Hans and Marit Rausing Charitable Fund
The Damman Foundation
Swedish Society for Medical Research(SLS),Goljes Memory Foundation
Magnus Bergvalls Foundation
Swedish Society for Medical Research(SSMF)and Tore Nilsons Foundation
