摘要
AIM: To contrast the effects of various modifications of body fluid volumes on thirst as reported by healthy volunteers. METHODS: Ten male volunteers aged between 19 and 37 years(mean 22 years) underwent four experiments each, which comprised infusion of 400-800 m L of acetated Ringer's solution and intake of 600 m L of tap water. Half of the experiments were preceded by volume depletion(median 1.7 L) with furosemide. A visual analogue scale(0-100 mm) was used to assess perceived thirst during each experiment. RESULTS: Volume depletion(P < 0.001) and tap water(P < 0.03) both affected thirst by 13 mm per L of fluid, whereas spontaneous diuresis and infusion of Ringer's acetate did not significantly change the thirst rating(multiple regressions). More detailed analyses showed that the volume depletion increased the median(25th-75th percentiles) thirst rating from 28 mm(21-43) to 59 mm(46-72, P < 0.001) while no change occurred in those who were only slightly thirsty(< 30 mm) before the volume depletion began. Ringer's solution alleviated thirst in those who were very thirsty, but tended to increase thirst in the volunteers who were not thirsty before the infusion. Similarly, hydration with tap water decreased thirst(by 24 mm, P < 0.04) in those who were thirsty(> 60 mm) while the others reported no change.
AIM: To contrast the effects of various modifications of body fluid volumes on thirst as reported by healthy volunteers. METHODS: Ten male volunteers aged between 19 and 37 years(mean 22 years) underwent four experiments each, which comprised infusion of 400-800 m L of acetated Ringer's solution and intake of 600 m L of tap water. Half of the experiments were preceded by volume depletion(median 1.7 L) with furosemide. A visual analogue scale(0-100 mm) was used to assess perceived thirst during each experiment. RESULTS: Volume depletion(P < 0.001) and tap water(P < 0.03) both affected thirst by 13 mm per L of fluid, whereas spontaneous diuresis and infusion of Ringer's acetate did not significantly change the thirst rating(multiple regressions). More detailed analyses showed that the volume depletion increased the median(25th-75th percentiles) thirst rating from 28 mm(21-43) to 59 mm(46-72, P < 0.001) while no change occurred in those who were only slightly thirsty(< 30 mm) before the volume depletion began. Ringer's solution alleviated thirst in those who were very thirsty, but tended to increase thirst in the volunteers who were not thirsty before the infusion. Similarly, hydration with tap water decreased thirst(by 24 mm, P < 0.04) in those who were thirsty(> 60 mm) while the others reported no change.
