摘要
背景:单宁酸在生物学和药理方面具有极强的活性,现已被应用于工业、医疗等领域。国内外对单宁酸的研究方兴未艾,单宁酸被认为是一种极具研究价值的材料。目的:分析单宁酸的生物活性及化学特性,综述其在工业、医学、口腔医学等领域的应用及展望。方法:应用计算机检索PubMed数据库、万方数据库、中国知网数据库、维普数据库中有关单宁酸的文献,中文检索词为"单宁酸,化学性质;单宁酸,生物活性;单宁酸,抗氧化性;单宁酸,工业;单宁酸,医学;单宁酸,口腔医学;单宁酸,牙本质;单宁酸,龋病;单宁酸,粘接强度"等,英文检索词为"tannic acid and chemical property,tannic acid and biological activity,tannin and antioxidant activity,tannin and industry,tannin and medicine,tannin and dentistry,tannin and dentin,tannin and tooth decay,tannin and bond strength"等。结果与结论:单宁酸为一种复杂的高分子多元酚类化合物,具有较强的功能性与生物学活性,因此被广泛应用于工业中。在医学领域,单宁酸不仅具有抑菌、抗病毒、抗炎、抗氧化等作用,并具有降血糖、降压、降脂等生理活性,而且对癌症与肿瘤有一定的抑制作用。在口腔领域,单宁酸可抑制致龋细菌的生长及牙齿菌斑生物膜的形成、保护牙周膜、预防牙釉质的表层脱矿及促进牙釉质的再矿化。基于单宁酸已知的生物学特点,其在心血管疾病、龋病的防治、麻醉等方面具有巨大科学研究价值。
BACKGROUND:Tannic acid has strong activity in biology and pharmacology,which has been used in industry,medical treatment and etc.Research focusing on tannic acid is in the ascendant,and tannic acid has been considered as a promising material with high research value.OBJECTIVE:To analyze the biological activity and chemical characteristics of tannic acid,and to review its application and prospect in industry,medicine and dentistry.METHODS:We searched the articles about tannic acid in PubMed database,WanFang database,CNKI database and VIP database with the key words of“tannic acid and chemical property,tannic acid and biological activity,tannin and antioxidant activity,tannin and industry,tannin and medicine,tannin and dentistry,tannin and dentin,tannin and tooth decay,tannin and bond strength”in English and Chinese,respectively.RESULTS AND CONCLUSION:As a complex polymer polyphenol,tannic acid has strong functional and biological activity and has been widely used in industry.In medicine,tannic acid not only has bacteriostatic,antiviral,anti-inflammatory,anti-oxidation effects and physiological activities,such as,lowering blood sugar,blood pressure,lipid and so on,but is also able to inhibit the growth of cancer and tumor.In dentistry,tannic acid can inhibit the growth of cariogenic bacteria and the formation of dental plaque biofilm,protect periodontal membrane,prevent the surface demineralization of enamel and promote the re-mineralization of the enamel.As the known biological characteristics of tannic acid,it still has a huge scientific research value in the prevention and treatment of cardiovascular disease and caries as well as in anesthesia.
作者
卞雨晴
马一丹
代东跃
苏平
贾梦奇
战德松
付佳乐
Bian Yuqing;Ma Yidan;Dai Dongyue;Su Ping;Jia Mengqi;Zhan Desong;Fu Jiale(School of Stomatology,China Medical University,Shenyang 110002,Liaoning Province,China;Department of Oral Materials,School of Stomatology,China Medical University,Shenyang 110002,Liaoning Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第2期284-290,共7页
Chinese Journal of Tissue Engineering Research
基金
2018年中国医科大学大学生创新创业训练计划资助项目(1111251703)
中国医科大学新教师基金(XZR20160015
项目负责人:付佳乐)~~
